Biodistribution of etoposide via intratumoral chemotherapy with etoposide-loaded implants
نویسندگان
چکیده
منابع مشابه
Cisplatin and Etoposide Combination Chemotherapy
Background: Thymomas are rare neoplasms of the mediastinum. The role of chemotherapy in advanced thymomas is not fully established. Patients and Methods: In the European Organization for Research and Treatment of Cancer (EORTC) Lung Cancer Cooperative Group, 16 patients with recurrent or metastatic malignant thymoma were entered over 6 years onto a study of combination chemotherapy that consist...
متن کاملPlasma etoposide catechol increases in pediatric patients undergoing multiple-day chemotherapy with etoposide.
PURPOSE The purpose of this research was to determine inter- and intrapatient differences in the pharmacokinetic profiles of etoposide and its genotoxic catechol metabolite during conventional multiple-day dosing of etoposide in pediatric patients. EXPERIMENTAL DESIGN Seven pediatric patients with various malignancies received etoposide at a dose of 100 mg/m(2) i.v. over 1 h daily for 5 days....
متن کاملOutcome of treatment with EMA/EP (etoposide methotrexate and actinomycin-D/ etoposide and cisplatin) regimen in gestational trophoblastic neoplasia
Background: Gestational trophoblastic neoplasia (GTN) originates from placental trophoblast and is a highly chemosensitive and curable gynecologic malignancy. The present study was conducted to evaluate the effectiveness and safety of EMA/EP (etoposide, methotrexate, actinomycin-D, etoposide, and cisplatin) regimen in the treatment of high-risk GTN as well as patients’ outcome. &nb...
متن کاملEtoposide pathway.
Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, Department of Medicine, University of Chicago, Illinois, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, Departments of Genetics and Bioengineering, Stanford University, Stanford, California, USA Correspondence to Dr Teri E. Klein, PhD, Department of Genetics,...
متن کاملMolecular mechanisms of etoposide
Etoposide derives from podophyllotoxin, a toxin found in the American Mayapple. It was first synthesized in 1966 and approved for cancer therapy in 1983 by the U.S. Food and Drug Administration (Hande, 1998[25]). Starting from 1980s several studies demonstrated that etoposide targets DNA topoisomerase II activities thus leading to the production of DNA breaks and eliciting a response that affec...
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ژورنال
عنوان ژورنال: Drug Delivery
سال: 2020
ISSN: 1071-7544,1521-0464
DOI: 10.1080/10717544.2020.1787558